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Dexmedetomidine hydrochloride

Name: Dexmedetomidine hydrochloride
Brand: TargetMol
SKU: T6466
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6466Cas No. 145108-58-3

Alias Precedex, Dexmedetomidine HCl, (S)-Medetomidine hydrochloride, (+)-Medetomidine hydrochloride

Dexmedetomidine hydrochloride (Precedex) is a potent, selective, orally active α2-adrenoceptor agonist with a Ki value of 1.08 nM. It shows 1620-fold selectivity over α1-adrenoceptors. Dexmedetomidine hydrochloride (Precedex) can protect against sepsis-induced acute lung injury through anti-inflammatory, anti-oxidative, and anti-apoptotic effects.

Dexmedetomidine hydrochloride

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Purity: 99.94%

Catalog No. T6466Alias Precedex, Dexmedetomidine HCl, (S)-Medetomidine hydrochloride, (+)-Medetomidine hydrochlorideCas No. 145108-58-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	In Stock	In Stock
10 mg	$50	In Stock	In Stock
25 mg	$90	In Stock	In Stock
50 mg	$162	In Stock	In Stock
100 mg	$238	In Stock	In Stock
200 mg	$358	In Stock	In Stock
500 mg	$593	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Dexmedetomidine hydrochloride (Precedex) is a potent, selective, orally active α2-adrenoceptor agonist with a Ki value of 1.08 nM. It shows 1620-fold selectivity over α1-adrenoceptors. Dexmedetomidine hydrochloride (Precedex) can protect against sepsis-induced acute lung injury through anti-inflammatory, anti-oxidative, and anti-apoptotic effects.
Targets&IC50	α2-adrenoceptor:1.08 nM (IC50)
In vitro	METHODS: NR8383 alveolar macrophages were stimulated with 10 μg/ml LPS for 24 hours and then treated with Dexmedetomidine hydrochloride (Precedex) (0.01, 0.1, 1, 10, 50 μM, 2 hours) for another 2 hours. CCK-8 assay was used to evaluate the effect of different concentrations of Dexmedetomidine hydrochloride (Precedex) pretreatment on the viability of LPS-treated NR8383 cells. RESULTS Cell viability gradually increased with increasing concentrations of Dexmedetomidine hydrochloride (Precedex). [1]
In vivo	METHODS: Using C57BL/6J mice exposed to LPS, we investigated whether Dexmedetomidine hydrochloride (Precedex) (50 μg/kg, intraperitoneal injection) provides lung protection by regulating mitochondrial dynamics via the HIF-1a/HO-1 pathway in vivo. RESULTS Dexmedetomidine hydrochloride (Precedex) alleviated lung pathological damage, reduced the oxidative stress index (OSI), improved mitochondrial dysfunction, upregulated the expression of HIF-1α and HO-1, and was accompanied by a shift in mitochondrial dynamics to fusion. [1]
Kinase Assay	In vitro HDAC assay:HDAC activity is analyzed by using an HDAC assay kit. This assay is based on the ability of DU-145 nuclear extract, which is rich in HDAC activity, to mediate the deacetylation of the biotinylated [3H]-acetyl histone H4 peptide that is bound to streptavidin agarose beads. The release of [3H]-acetate into the supernatant is measured to calculate the HDAC activity. Sodium butyrate (0.25-1 mM) is used as a positive control.
Synonyms	Precedex, Dexmedetomidine HCl, (S)-Medetomidine hydrochloride, (+)-Medetomidine hydrochloride

Chemical Properties

Molecular Weight	236.74
Formula	C₁₃H₁₆N₂·HCl
Cas No.	145108-58-3
Smiles	Cl.C[C@H](c1cnc[nH]1)c1cccc(C)c1C
Relative Density.	1.17 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (232.32 mM), Sonication is recommended.

H2O: 23.7 mg/mL (100.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.45 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2240 mL	21.1202 mL	42.2404 mL	211.2022 mL
5 mM	0.8448 mL	4.2240 mL	8.4481 mL	42.2404 mL
10 mM	0.4224 mL	2.1120 mL	4.2240 mL	21.1202 mL
20 mM	0.2112 mL	1.0560 mL	2.1120 mL	10.5601 mL
50 mM	0.0845 mL	0.4224 mL	0.8448 mL	4.2240 mL
100 mM	0.0422 mL	0.2112 mL	0.4224 mL	2.1120 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc